Humane endpoints
Pain Management and Humane Endpoints Workshop
Data Base http://altweb.jhsph.edu/humane-endpoints.htm
Pain & Distress Report
A quarterly newsletter published by the Humane Society of the United States this is a valuable resource for researchers, members of AEC’s and animal care personnel providing current information on issues relating to the assessment and relief of pain and distress including summaries of recent developments in policies and perspectives, articles from the technical and scientific literature, publications, resources, services, upcoming conferences and web sites. www.hsus.org/animals_in_research/pain_distress/
Humane Endpoints for Animal Experiments for Biomedical Research
Proceedings of the 1998 International conference held in the Netherlands. Edited by Coenraad Hendriksen and David Morton, contents include, human neonates and pain, criteria for humane endpoints, an applied approach to the assessment of severity, practical use of distress scoring systems, relating criteria for humane endpoints to objectives and discussions of issues in toxicity testing, cancer research, vaccine production and re-use of animals. Download copies of the proceedings.
Pain Management and Humane Endpoints
An information resource published by the Animal Welfare Information Centre (USDA) which includes a discussion paper on setting acceptable endpoints in invasive experiments, assessment and alleviation of post-operative pain, guidelines for euthanasia of mouse and rat fetuses and neonates and an extensive bibliography. Copies can be download from: www.nal.usda.gov/awic/pubs/IACUC/pain.htm
Canadian Council on Animal Care
Guidelines for choosing appropriate endpoints in experiments using animals for research, teaching and testing (1998) - the purpose of this document is to present guidelines for selecting an endpoint that reduces animal pain and/or distress in laboratory animals, while still satisfying the experimental design requirements for objective evaluation when animals are used in biomedical research, teaching and testing. These guidelines should be as a guide to the ongoing process of refinement in animal experimentation.
www.ccac.ca/en/CCAC_Programs/Guidelines_Policies/GDLINES/ENDPTS/g_endpoints.pdf
Organisation for Economic Co-operation and Development (OECD)
The purpose of this Guidance Document is to apply the principles of the Three Rs to the use of animals in regulatory toxicity tests. This document is a guide to the recognition, assessment, and use of clinical signs as humane endpoints for experimental animals used in safety evaluation. The general principles contained in this document are specifically designed to be applicable for all mammalian species used in toxicity testing and other experimental studies.
http://www.olis.oecd.org/olis/2000doc.nsf/LinkTo/env-jm-mono(2000)7