Administration of substances

A Good Practice Guide to the Administration of Substances and Removal of Blood, including Routes and Volumes.

European Federation of Pharmaceutical Industries Association and the European Centre for the Validation of Alternative Methods. Contains information on administration volumes considered good practice for the mouse, rat, rabbit, dog, marmoset and mini-pig, animal welfare issues with different routes, repeated intravenous infusions and vehicles for administration. Includes an extensive bibliography.

www.eslav.org/efpia.htm

Refining procedures for the administration of substances

Morton, D. B.; Jennings, M.; Buckwell, A.; Ewbank, R.; Godfrey, C.
Holgate, B.; Inglis, I.; James, R.; Page, C.; Sharman, I.; Verschoyle, R;
Westall, L.; Wilson, A. B.
www.lal.org.uk/pdffiles/refinement.pdf